Intellectual Property—19 Issued or Allowed Patents

Glycotest IP strategy is to enable multiple layers of protection for key liver disease tests through multiple patent families prosecuted in commercially important jurisdictions—individual biomarkers; assay technology; panels and algorithms


HCC Panel patent application (PCT/US2017/018040 and Taiwan 106106107)

  • Panels and algorithms, including the HCC Panel
  • Protection to 2037, including in China


  • Engineered lectins and methods for fucosylated biomarker assays
  • Issued European (2462240) and Chinese (ZL201080044720.8) patents
  • Protection to 2030, including in China


  • Methods for diagnosing liver disease using fucosylated biomarkers
  • Issued US (7,776,550; 8,183,000; 10,082,512; 10,823,740), European (3056905; 3578985), Australian (2006244398; 2012247075; 2015275300), Japanese (5964769; 6184935; 6553142), Canadian (2607285), and Hong Kong (HK1228005) patents and allowed   Canadian patent
  • Protection to 2026


  • Methods for diagnosing liver disease using fucosylated LRAGG
  • Issued US patents (9,110,078; 10,180,436)
  • Protection to 2028

Trade Secrets

  • Fucosylated biomarker assay manufacturing technology
  • Fucosylated biomarker assay methods


• Exploits unique disease signal chemistry (glycoprotein fucosylation) present in liver cancers and fibrosis-cirrhosis but absent in healthy individualsIncorporated into highly promising biomarker panels

• Focused on the detection of potentially curable early-stage disease

• May outperform currently available serum biomarkers, such as AFP

• Targeting the worldwide liver cancer threat that kills more than 700,000 people annually and is the fastest growing cause of cancer death in the US


A New Paradigm for Early Diagnosis and Surveillance For Liver Cancer


Glycotest blood tests are being developed to provide information on the likelihood of serious liver disease like cancer or fibrosis-cirrhosis by employing technology designed to measure two kinds of disease signals:
• The amount of the monosaccharide fucose that appears abnormally on certain serum glycoproteins—to indicate likelihood of disease.
• The pattern of glycoproteins that is abnormally fucosylated—to monitor specific diseases like HCC, CCA or fibrosis-cirrhosis.
Intellectual Property | Glycotest Diagnostics